*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OH4725000
CHEMICAL NAME           : Leucomycin A1
CAS REGISTRY NUMBER     : 16846-34-7
LAST UPDATED            : 199107
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C40-H67-N-O14
MOLECULAR WEIGHT        : 786.08
WISWESSER LINE NOTATION : T-16-OV KU MUTJ DQ EO1 G1VH I1 JQ P1 FO- BT6OTJ CQ
                          DN1&1 F1 EO- BT6OTJ DQ D1 EOV1Y1&1 F1
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * 9-Dihydroniddamycin
   * Leucomycin V, 4B-(3-methylbutanoate)
   * LM-A1
   * Turimycin H5
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAJAAA Journal of Antibiotics, Series A.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JANTAJ.  Volume(issue)/page/year: 19,30,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Behavioral - irritability
   Lungs, Thorax, or Respiration - respiratory stimulation
   Skin and Appendages - hair
REFERENCE :
   JAJAAA Journal of Antibiotics, Series A.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JANTAJ.  Volume(issue)/page/year: 19,30,1966
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Behavioral - irritability
   Lungs, Thorax, or Respiration - respiratory stimulation
   Skin and Appendages - hair
REFERENCE :
   JAJAAA Journal of Antibiotics, Series A.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JANTAJ.  Volume(issue)/page/year: 19,30,1966
 
                            *** END OF RECORD ***