*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OG3675000
CHEMICAL NAME           : Lead(II) phosphate (3:2)
CAS REGISTRY NUMBER     : 7446-27-7
LAST UPDATED            : 199712
DATA ITEMS CITED        : 34
MOLECULAR FORMULA       : O8-P2.3Pb
MOLECULAR WEIGHT        : 811.51
WISWESSER LINE NOTATION :  PB3 P-O4*2
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Bleiphosphat
   * C.I. 77622
   * Collodial lead phosphate
   * Lead orthophosphate
   * Lead phosphate
   * Lead phosphate (3:2)
   * Lead(2+) phosphate
   * Normal lead orthophosphate
   * Perlex paste 500
   * Perlex paste 600A
   * Phosphoric acid, lead(2+) salt (2:3)
   * Plumbous phosphate
   * RCRA waste number U145
   * Trilead phosphate
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 540 mg/kg/6W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   APAVAY Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und
   fuer Klinische Medizin. (Berlin, Ger.)  V.1-343, 1847-1967.  For publisher
   information, see VAAPB7.  Volume(issue)/page/year: 323,694,1953
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 580 mg/kg/34W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   19,860,1965

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 0.05 mg(Pb)/m3; animal carcinogen
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   IARC Cancer Review:Human Limited Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 23,325,1980

   IARC Cancer Review:Animal Sufficient Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 23,325,1980

   IARC Cancer Review:Human Inadequate Evidence
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,230,1987

   IARC Cancer Review:Group 2B
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,230,1987

   TOXICOLOGY REVIEW
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 9,105,1971

   TOXICOLOGY REVIEW
   PEXTAR Progress in Experimental Tumor Research.  (S. Karger AG, Postfach
   CH-4009 Basel, Switzerland) V.1-    1960-  Volume(issue)/page/year:
   12,102,1969

   TOXICOLOGY REVIEW
   85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
   Washington, DC, National Academy of Sciences, 1972-77
   Volume(issue)/page/year: Pb,259,1972

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-ARAB Republic of Egypt:TWA 0.05 mg(Pb)/m3 JAN 1993
   
   OEL-AUSTRALIA:TWA 0.15 mg(Pb)/m3 JAN 1993
   
   OEL-AUSTRIA:TWA 0.1 mg(Pb)/m3 JAN 1993
   
   OEL-BELGIUM:TWA 0.15 mg(Pb)/m3 JAN 1993
   
   OEL-DENMARK:TWA 0.1 mg(Pb)/m3 JAN 1993
   
   OEL-FINLAND:TWA 0.1 mg(Pb)/m3 JAN 1993
   
   OEL-FRANCE:TWA 0.15 mg(Pb)/m3 JAN 1993
   
   OEL-GERMANY:TWA 0.1 mg(Pb)/m3 JAN 1993
   
   OEL-HUNGARY:STEL 0.04 mg(Pb)/m3;Carcinogen JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.15 mg(Pb)/m3 JAN 1993
   
   OEL-RUSSIA:STEL 0.005 ppm (0.01 mg(Pb)/m3) JAN 1993
   
   OEL-SWEDEN:TWA 0.05 mg(Pb)/m3 (resp. dust) JAN 1993
   
   OEL-SWEDEN:TWA 0.1 mg(Pb)/m3 (total dust) JAN 1993
   
   OEL-SWITZERLAND:TWA 0.1 mg(Pb)/m3 JAN 1993
   
   OEL-THAILAND:TWA 0.2 mg(Pb)/m3 JAN 1993
   
   OEL-TURKEY:TWA 0.2 mg(Pb)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.15 mg(Pb)/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO LEAD, INORGANIC-air:10H TWA <0.1 mg(Pb)/m3
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83915
       No. of Facilities: 54 (estimated)
       No. of Industries: 2
       No. of Occupations: 4
       No. of Employees: 1134 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen

 
                            *** END OF RECORD ***