*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OG1750000
CHEMICAL NAME : Lead monoxide
CAS REGISTRY NUMBER : 1317-36-8
LAST UPDATED : 199712
DATA ITEMS CITED : 33
MOLECULAR FORMULA : O-Pb
MOLECULAR WEIGHT : 223.19
WISWESSER LINE NOTATION : PB O
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* C.I. 77577
* C.I. Pigment Yellow 46
* Lead monooxide
* Lead oxide
* Lead Oxide Yellow
* Lead protoxide
* Lead(II) oxide
* Litharge
* Litharge Pure
* Litharge Yellow L-28
* Plumbous oxide
* Yellow Lead Ocher
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
30,168,1975
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 430 mg/kg
TOXIC EFFECTS :
Blood - other changes
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher
information, see IOHSA5. Volume(issue)/page/year: 10,15,1941
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 ug/m3/24H/22W-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - changes in bone marrow (not otherwise specified)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 43(6),96,1978
** MUTATION DATA **
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 50 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,193,1979
*** REVIEWS ***
ACGIH TLV-TWA 0.05 mg(Pb)/m3; animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 23,325,1980
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Pb,254,1972
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.05 mg(Pb)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.15 mg(Pb)/m3 JAN 1993
OEL-AUSTRIA:TWA 0.1 mg(Pb)/m3 JAN 1993
OEL-BELGIUM:TWA 0.15 mg(Pb)/m3 JAN 1993
OEL-DENMARK:TWA 0.1 mg(Pb)/m3 JAN 1993
OEL-FINLAND:TWA 0.1 mg(Pb)/m3 JAN 1993
OEL-FRANCE:TWA 0.15 mg(Pb)/m3 JAN 1993
OEL-GERMANY:TWA 0.1 mg(Pb)/m3 JAN 1993
OEL-HUNGARY:STEL 0.04 mg(Pb)/m3;Carcinogen JAN 1993
OEL-THE PHILIPPINES:TWA 0.15 mg(Pb)/m3 JAN 1993
OEL-RUSSIA:STEL 0.005 ppm (0.01 mg(Pb)/m3) JAN 1993
OEL-SWEDEN:TWA 0.05 mg(Pb)/m3 (resp. dust) JAN 1993
OEL-SWEDEN:TWA 0.1 mg(Pb)/m3 (total dust) JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(Pb)/m3 JAN 1993
OEL-THAILAND:TWA 0.2 mg(Pb)/m3 JAN 1993
OEL-TURKEY:TWA 0.2 mg(Pb)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.15 mg(Pb)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO LEAD, INORGANIC-air:10H TWA <0.1 mg(Pb)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0125
No. of Facilities: 1613 (estimated)
No. of Industries: 35
No. of Occupations: 37
No. of Employees: 23488 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0125
No. of Facilities: 2531 (estimated)
No. of Industries: 40
No. of Occupations: 47
No. of Employees: 59832 (estimated)
No. of Female Employees: 19722 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1994: Lead, by flame AAS, 7082; or by HGAAS, 7105
*** END OF RECORD ***