*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OD2400000
CHEMICAL NAME           : Lactamide, N-(2-hydroxyethyl)-
CAS REGISTRY NUMBER     : 5422-34-4
BEILSTEIN REFERENCE NO. : 1702912
REFERENCE               : 4-04-00-01555 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C5-H11-N-O3
MOLECULAR WEIGHT        : 133.17
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * N-Hydroxyaethyllactamid
   * N-(beta-Hydroxyethyl)lactamide
   * Propanamide, 2-hydroxy-N-(2-hydroxyethyl)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 24 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 9,711,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16300 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Vascular - other changes
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 28,1579,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 9,711,1959
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 mg/plate
REFERENCE :
   APHGAO Acta Pharmaceutica Hungarica.  (Kultura, POB 149, H-1389 Budapest,
   Hungary)  1953-    Adopts V.24 in 1955.  Volume(issue)/page/year: 56,97,1986
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 50 gm/L
REFERENCE :
   APHGAO Acta Pharmaceutica Hungarica.  (Kultura, POB 149, H-1389 Budapest,
   Hungary)  1953-    Adopts V.24 in 1955.  Volume(issue)/page/year: 56,97,1986
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 gm/L
REFERENCE :
   APHGAO Acta Pharmaceutica Hungarica.  (Kultura, POB 149, H-1389 Budapest,
   Hungary)  1953-    Adopts V.24 in 1955.  Volume(issue)/page/year: 56,97,1986

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***