*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OB2450000
CHEMICAL NAME : Ketone, 10-(3-(dimethylamino)propyl)phenothiazin-2-yl
methyl, maleate (1:1)
CAS REGISTRY NUMBER : 3598-37-6
OTHER CAS REGISTRY NOS. : 2664-15-5
LAST UPDATED : 199707
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C19-H22-N2-O-S.C4-H4-O4
MOLECULAR WEIGHT : 442.57
WISWESSER LINE NOTATION : T C666 BN ISJ B3N1&1 EV1 &OV1U1VO
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* Acepromazine maleate
* 2-Acetyl-10-(3-(dimethylamino)propyl)phenothiazine, maleate
* Acetylpromazine maleate (1:1)
* Anatran
* 10-(3-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone maleate (1:1)
* Ethanone, 1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-,
(Z)-2-butenedioate (1:1)
* Maleate acide de l'acetyl 3-dimethylamino 3-propyl-10-phenothiazine
* Notensil maleate
* Phenothiazine, 2-acetyl-10-(3-(dimethylamino)propyl)-, maleate
* Plegicil maleate
* Soprontin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - child
DOSE/DURATION : 6250 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Cardiac - pulse rate increase, without fall in BP
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia,
PA) V.1- 1983- Volume(issue)/page/year: 11,247,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 123,78,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 95 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
11,6,1989
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 113,53,1957
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 113,53,1957
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
19,87,1962
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1537
No. of Facilities: 315 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 2207 (estimated)
No. of Female Employees: 946 (estimated)
*** END OF RECORD ***