*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OB2275000
CHEMICAL NAME           : Ketone, 10-(3-(dimethylamino)propyl)phenothiazin-2-yl
                          methyl
CAS REGISTRY NUMBER     : 61-00-7
LAST UPDATED            : 199707
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C19-H22-N2-O-S
MOLECULAR WEIGHT        : 326.49
WISWESSER LINE NOTATION : T C666 BN ISJ B3N1&1 EV1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acepromazina
   * Acepromazine
   * Acetopromazine
   * 2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine
   * Acetylpromazine
   * Anergan
   * Atsetozin
   * AY-57,062
   * Azepromazine
   * 1522 CB
   * 10-(3-Dimethylaminopropyl)phenothiazine-3-ethylone
   * 1-(10-(3-(Dimethylamino)propyl)-10H-phenothiazin-2-yl)ethanone
   * 10-(3-Dimethylaminopropyl)phenothiazin-3-yl methyl ketone
   * Ethanone, 1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-
   * Notensil
   * Plegicil
   * Plivafen
   * Promazine, acetyl-
   * SV-1522
   * Vetranquil
   * WY-1172
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 24,136,1961
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 113,53,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RMNIBN Revista Medico-Chirurgicala.  Medical-Surgical Journal.  (Societatea
   de Medici si Naturalisti, 16 Bulevardul Independentei, Iasi, Romania) V.35- 
     1924-  Volume(issue)/page/year: 81,105,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 113,53,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 59 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 115,1,1958

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   JMSCA9 Journal of Mental Science.  (London, UK)  V.4-108, 1857-1962.  For
   publisher information, see BJPYAJ.  Volume(issue)/page/year: 106,755,1960

   TOXICOLOGY REVIEW
   IDPYAK Industrial Pharmacology.  (Mount Kisco, NY)  V.1-3, 1974-79.
   Discontinued.  Volume(issue)/page/year: 1,203,1974

 
                            *** END OF RECORD ***