*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NY2100000
CHEMICAL NAME           : 5-Isoxazoleacetic acid, alpha-amino-3-hydroxy-,
                          monohydrate
CAS REGISTRY NUMBER     : 60573-88-8
LAST UPDATED            : 199012
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C5-H6-N2-O4.H2-O
MOLECULAR WEIGHT        : 176.15
WISWESSER LINE NOTATION : T5NOJ CYZVQ EQ &QH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * alpha-Amino-2,3-dihydro-3-oxo-5-isoxazoleacetic acid
   * alpha-Amino-3-hydroxy-5-isoxazoleacetic acid hydrate
   * alpha-Amino-3-hydroxy-5-isoxazolessigsaure hydrat
   * Amino-(3-hydroxy-5-isoxazolyl)acetic acid
   * Ibotenic acid
   * Ibotensaeure
   * Isotenic acid
   * Pramuscimol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 129 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,311,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,311,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 38 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,311,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,311,1968

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   LLOYA2 Lloydia.  (Cincinnati, OH)  V.1-41, 1938-78.  For publisher
   information, see JNPRDF.  Volume(issue)/page/year: 38,36,1975

 
                            *** END OF RECORD ***