*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX8155650
CHEMICAL NAME           : 4-Isothiazolecarboxamide,
                          5-(benzoylamino)-N-(p-chlorophenyl)-3-methyl-
CAS REGISTRY NUMBER     : 51287-57-1
LAST UPDATED            : 199406
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C18-H14-Cl-N3-O2-S
MOLECULAR WEIGHT        : 371.86
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 5-(Benzoylamino)-N-(p-chlorophenyl)-3-methyl-4-isothiazolecarboxamide
   * p-Chlorophenylamide of 3-methyl-5-benzoylaminoizothiazole-4-carboxylic  
   acid
   * ITCL
   * 3-Methyl-5-benzoylaminoisothiazole-4-carboxylic acid p-chlorophenylamide
   * T-15
   * Wratizolin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   28,393,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   28,393,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   28,393,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 219 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   28,393,1980
 
                            *** END OF RECORD ***