*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX7285000
CHEMICAL NAME           : 1-Isotetrandrine
CAS REGISTRY NUMBER     : 477-57-6
LAST UPDATED            : 199709
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C38-H42-N2-O6
MOLECULAR WEIGHT        : 622.82
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-
   * O,O'-Dimethylobamegine
   * O,O'-Dimethylstepholine
   * Isosinomenin A
   * Isosinomenine A
   * Isotetrandrine
   * (+)-Isotetrandrine
   * O-Methylberbamine
   * 6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman
   * (R,S)-Tetrandrine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   65(5),176S,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 24,2413,1976
 
                            *** END OF RECORD ***