*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX6039250
CHEMICAL NAME           : 3(2H)-Isoquinolinone,
                          5,6,7,8-tetrahydro-4-acetyl-1-methyl-7-(4-pyridinyl)-
CAS REGISTRY NUMBER     : 107189-96-8
BEILSTEIN REFERENCE NO. : 6416236
LAST UPDATED            : 199612
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C17-H18-N2-O2
MOLECULAR WEIGHT        : 282.37
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-Acetyl-1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)-isoquinolinone
   * MS 857
   * 5,6,7,8-Tetrahydro-4-acetyl-1-methyl-7-(4-pyridinyl)-3(2H)-isoquinolinone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 147 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,425,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,425,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 136 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,425,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 377 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,425,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,425,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 171 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,425,1992
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,425,1992
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10920 mg/kg/91D-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Related to Chronic Data - death
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,425,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10950 mg/kg/1Y-I
TOXIC EFFECTS :
   Blood - changes in spleen
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Endocrine - changes in adrenal weight
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,425,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 5460 mg/kg/91D-I
TOXIC EFFECTS :
   Endocrine - changes in adrenal weight
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,425,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 4562 mg/kg/1Y-I
TOXIC EFFECTS :
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,425,1992
 
                            *** END OF RECORD ***