*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX6010000
CHEMICAL NAME           : 7-Isoquinolinol,
                          1,2,3,4-tetrahydro-6-methoxy-1-methyl-,
                          hydrochloride, (1R)-(+)-
CAS REGISTRY NUMBER     : 51366-07-5
LAST UPDATED            : 199012
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C11-H15-N-O2.Cl-H
MOLECULAR WEIGHT        : 229.73
WISWESSER LINE NOTATION : T66 CMT&J B1 HO1 IQ &GH -1R(+)
SYNONYMS/TRADE NAMES :
   * (1R)-(+)-7-Hydroxy-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline  
   hydrochloride
   * 7-Isoquinolinol, 6-methoxy-1-methyl-1,2,3,4-tetrahydro-, hydrochloride,  
   (1R)-(+)-
   * (R)-(+)-Isosalsoline hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 17,134,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 17,134,1974
 
                            *** END OF RECORD ***