*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX5070700
CHEMICAL NAME           : Isoquinoline,
                          1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratryl-,
                          hydrochloride
CAS REGISTRY NUMBER     : 6429-04-5
LAST UPDATED            : 198310
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H25-N-O4.Cl-H
MOLECULAR WEIGHT        : 379.92
WISWESSER LINE NOTATION : T66 CMT&J B1R CO1 DO1& HO1 IO1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1,2,3,4-Tetrahydro-6,7-dimethoxy-1-veratryl-isoquinoline hydrochloride
   * Tetrahydropapaverine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 149,200,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 149,200,1964
 
                            *** END OF RECORD ***