*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX5018500
CHEMICAL NAME           : Isoquinoline,
                          1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-
CAS REGISTRY NUMBER     : 493-48-1
LAST UPDATED            : 199312
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C12-H17-N-O2
MOLECULAR WEIGHT        : 207.30
WISWESSER LINE NOTATION : T66 CMT&J B1 HO1 IO1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
   * Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-
   * Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-, (S)-
   * Salsolidin
   * Salsolidine
   * (-)-Salsolidine
   * (S)-Salsolidine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 41,249,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KHFZAN Khimiko-Farmatsevticheskii Zhurnal.  Chemical Pharmaceutical Journal.
    For English translation, see PCJOAU.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.1-    1967-  Volume(issue)/page/year: 15(2),54,1981
 
                            *** END OF RECORD ***