*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NW7628980
CHEMICAL NAME           : Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-veratryl-,
                          hydrochloride
CAS REGISTRY NUMBER     : 5884-22-0
LAST UPDATED            : 198609
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H23-N-O4.Cl-H
MOLECULAR WEIGHT        : 377.90
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Chlorhydrate de dihydropapaverine
   * 3,4-Dihydro-6,7-dimethoxy-1-veratrylisoquinoline hydrochloride
   * Dihydropapaverine hydrochloride
   * 3,4-Dihydropapaverine hydrochloride
   * 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline  
   hydrochloride
   * 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-3,4-dihydroisoquinoline  
   hydrochloride
   * Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-((3,4-dimethoxyphenyl)methyl)-, 
    hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   APPBDI Acta Physiologica et Pharmacologica Bulgarica.  (Izdatelstvo na
   Bulgarskata Akademiya na Naukite, ul. Akad. G. Bonchev, 1113 Sofia,
   Bulgaria)  V.1-    1974-  Volume(issue)/page/year: 5(3),82,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 5,69,1950
 
                            *** END OF RECORD ***