*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NW7524100
CHEMICAL NAME           : Isoquinoline, 1-(3,4-diethoxybenzyl)-6,7-diethoxy-,
                          hydrochloride
CAS REGISTRY NUMBER     : 985-13-7
LAST UPDATED            : 199701
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C24-H29-N-O4.Cl-H
MOLECULAR WEIGHT        : 432.00
WISWESSER LINE NOTATION : T66 CNJ B1R CO2 DO2& HO2 FO2 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Barbonin hydrochloride
   * 1-(3,4-Diethoxybenzyl)-6,7-diethoxyisoquinoline hydrochloride
   * Ethaverine hydrochloride
   * Isoquinoline, 1-((3,4-diethoxyphenyl)methyl)-6,7-diethoxy-, hydrochloride
   * Papetherine hydrochloride
   * Perparine hydrochloride
   * Perparin hydrochloride
   * Perperine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 660 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 5,69,1950
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 86 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 9,585,1951

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5434
       No. of Facilities: 26 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 1324 (estimated)
       No. of Female Employees: 667 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***