*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NS7700000
CHEMICAL NAME : Isooctyl alcohol
CAS REGISTRY NUMBER : 26952-21-6
LAST UPDATED : 199712
DATA ITEMS CITED : 25
MOLECULAR FORMULA : C8-H18-O
MOLECULAR WEIGHT : 130.26
WISWESSER LINE NOTATION : Q5Y1&1
COMPOUND DESCRIPTOR : Primary Irritant
SYNONYMS/TRADE NAMES :
* Isooctanol
* Isooctyl alcohol
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2600 mg/kg/24H
REACTION SEVERITY : Moderate
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
34,493,1973
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg
REACTION SEVERITY : Severe
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
34,493,1973
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1480 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
34,493,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1670 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,77,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2520 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
31ZTAS "Alcohols: Their Chemistry, Properties and Manufacture," Monick,
J.A., New York, Reinhold Book, 1968 Volume(issue)/page/year: -,72,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 39(4),86,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 1670 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 51(5),61,1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1500 ug/m3/24H/96D-C
TOXIC EFFECTS :
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 37(8),16,1972
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 600 mg/m3/6H/2W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in spleen weight
Blood - changes in erythrocyte (RBC) count
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570889
*** REVIEWS ***
ACGIH TLV-TWA 266 mg/m3 (50 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 50 ppm (270 mg/m3);Skin JAN 1993
OEL-BELGIUM:TWA 50 ppm (266 mg/m3);Skin JAN 1993
OEL-DENMARK:TWA 50 ppm (270 mg/m3);Skin JAN 1993
OEL-FRANCE:TWA 50 ppm (270 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 50 ppm (270 mg/m3) JAN 1993
OEL-RUSSIA:STEL 50 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 50 ppm (270 mg/m3);Skin JAN 1993
OEL-UNITED KINGDOM:TWA 50 ppm (270 mg/m3) (mixed isomers) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ISOOCTYL ALCOHOL-air:10H TWA 50 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83573
No. of Facilities: 160 (estimated)
No. of Industries: 6
No. of Occupations: 19
No. of Employees: 32085 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83573
No. of Facilities: 752 (estimated)
No. of Industries: 17
No. of Occupations: 22
No. of Employees: 12363 (estimated)
No. of Female Employees: 3300 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***