*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NS5300000
CHEMICAL NAME           : Isonipecotic acid,
                          1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl
                          ester, hydrochloride
CAS REGISTRY NUMBER     : 3810-80-8
LAST UPDATED            : 199712
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C30-H32-N2-O2.Cl-H
MOLECULAR WEIGHT        : 489.10
WISWESSER LINE NOTATION : T6NTJ A2XR&R&CN DVO2 DR &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid ethyl ester  
   hydrochloride
   * Diphenoxylate hydrochloride
   * Ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate  
   monohydrochloride
   * R 1132
   * R 1132 (antiperistaltic)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 221 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,1633,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,1636,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,1636,1974

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X3182
       No. of Facilities: 105 (estimated)
       No. of Industries: 1
       No. of Occupations: 4
       No. of Employees: 8242 (estimated)
       No. of Female Employees: 7235 (estimated)

 
                            *** END OF RECORD ***