*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NS5265200
CHEMICAL NAME           : Isonipecotic acid, 1-(2-benzoylethyl)-4-phenyl-,
                          ethyl ester, hydrochloride
CAS REGISTRY NUMBER     : 60789-94-8
LAST UPDATED            : 199707
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C23-H27-N-O3.Cl-H
MOLECULAR WEIGHT        : 401.97
WISWESSER LINE NOTATION : T6NTJ A2VR& DVO2 DR &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-(2-Benzoylethyl)-4-phenylisonipecotic acid ethyl ester hydrochloride
   * 2-(N-(4-Carbethoxy-4-phenyl)piperidino)propiophenone hydrochloride
   * 4-Piperidinecarboxylic acid, 1-(3-oxo-3-phenylpropyl)-4-phenyl-, ethyl  
   ester, hydrochloride
   * Propiophenone, 3-(N-(4'-carbethoxy-4'-phenyl)piperidino)-, hydrochloride
   * SC-8775
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 7,373,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >112 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 7,373,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 7,373,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 7,373,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 610 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 7,373,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,299,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 215 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 7,373,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 13800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 7,373,1958
 
                            *** END OF RECORD ***