*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NR3675000
CHEMICAL NAME           : Isoindolinium,
                          4,5,6,7-tetrachloro-2-methyl-2-(2-(trimethylammonio)e
                          thyl)-, dichloride
CAS REGISTRY NUMBER     : 69-27-2
OTHER CAS REGISTRY NOS. : 303-92-4
LAST UPDATED            : 199009
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C14-H20-Cl4-N2.2Cl
MOLECULAR WEIGHT        : 429.06
WISWESSER LINE NOTATION : T56 CKT&J C2K1&1&1 C1 FG GG HG IG &Q 2 &G 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Ammonium, (2-(2-methyl-4,5,6,7-tetrachloroisoindolinyl)ethyl)trimethyl-,  
   dichloride
   * Chlorisondamine
   * Chlorisondamine chloride
   * Chlorisondamine dimethochloride
   * N-((2-Dimethylammonium)ethyl)-4,5,6,7-tetrachloroisoindolinium  
   dimethochloride
   * Ecolid
   * Ecolid R
   * Ecolid chloride
   * Hisindamone A
   * Isoindoline, 2-(2-dimethylaminoethyl)-4,5,6,7-tetrachlorodimetho chloride
   * SU 3088
   * 4,5,6,7-Tetrachloro-2-(2-dimethylaminoethyl)-isoindoline dimethochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SKNEA7 Shionogi Kenkyusho Nenpo.  Annual Report of Shionogi Research
   Laboratory.  (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu, Fukushima-ku,
   Osaka 553, Japan)  No.1-    1951-  Volume(issue)/page/year: 10,15,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 115,172,1955
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   103,490,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 62 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 155,69,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 20,482,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#00058
 
                            *** END OF RECORD ***