*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NP7224500
CHEMICAL NAME           : 1(3H)-Isobenzofuranone,
                          6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methy
                          l-1,3-dioxolo (4,5-g)isoquinolin-5-yl)-, (R-(R*,R*))-
CAS REGISTRY NUMBER     : 3860-46-6
LAST UPDATED            : 198212
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H23-N-O7
MOLECULAR WEIGHT        : 413.46
WISWESSER LINE NOTATION : T C566 DO FO KN EH&&TJ HO1 K1 J- DT56 BVO DHJ HO1 IO1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * beta-Narcotine
   * L-beta-Narcotine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 840 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 12,569,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 255 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 12,569,1964
 
                            *** END OF RECORD ***