*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NO5400000
CHEMICAL NAME           : Iron(II) chloride (1:2)
CAS REGISTRY NUMBER     : 7758-94-3
LAST UPDATED            : 199712
DATA ITEMS CITED        : 20
MOLECULAR FORMULA       : Cl2-Fe
MOLECULAR WEIGHT        : 126.75
WISWESSER LINE NOTATION :  FE  G2
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Ferrous chloride
   * Iron dichloride
   * Iron protochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 39(5),16,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 59 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 244,17,1962
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6604 mg/kg/30D-C
TOXIC EFFECTS :
   Liver - other changes
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   VMDKAM Voprosy Meditsinskoi Khimii. Problems of Medical Chemistry.  (V/O Me
   zhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1955-
   Volume(issue)/page/year: 37(1),39,1991
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 ug/m3/24H/65D-C
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 50(7),73,1985
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 ng/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,349,1991
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 2500 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,193,1979

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 1 mg(Fe)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 1 mg(Fe)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   3,138,1971

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-DENMARK:TWA 1 mg(Fe)/m3 JAN 1993
   
   OEL-FINLAND:TWA 1 mg(Fe)/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 1 mg(Fe)/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 1 mg(Fe)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 1 mg(Fe)/m3;STEL 2 mg(Fe)/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 82179
       No. of Facilities: 361 (estimated)
       No. of Industries: 12
       No. of Occupations: 14
       No. of Employees: 2280 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 82179
       No. of Facilities: 187 (estimated)
       No. of Industries: 6
       No. of Occupations: 7
       No. of Employees: 7981 (estimated)
       No. of Female Employees: 1823 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
   
   EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***