*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NM9744000
CHEMICAL NAME           : Interleukin 4, human recombinant
LAST UPDATED            : 199606
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Recombinant human interleukin 4
   * RhuIL-4
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 700 ug/kg/28D-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Blood - changes in erythrocyte (RBC) count
   Related to Chronic Data - changes in testicular weight
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 64,299,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 5400 ug/kg/26W-I
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Related to Chronic Data - death
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 30,107,1996
 
                            *** END OF RECORD ***