*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NM2083780
CHEMICAL NAME           : 2-Indolinone, 3,3-bis(p-hydroxyphenyl)-
CAS REGISTRY NUMBER     : 125-13-3
BEILSTEIN REFERENCE NO. : 0286070
REFERENCE               : 5-21-13-00398 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H15-N-O3
MOLECULAR WEIGHT        : 317.36
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 3,3-Bis(p-hydroxyphenyl)-2-indolinone
   * 1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-2H-indol-2-one
   * 4,4'-Dihydroxydiphenylisatin
   * Diphenolisatin
   * Hoscolax
   * 2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-
   * Isatinbisphenol
   * Isolax
   * Lavema
   * Neodrast
   * Normalax
   * Oxyphenisatin
   * Oxyphenisatine
   * Phenolisatin
   * Propellax
   * Recolon
   * Veripaque
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 300 ug/kg/36H-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Liver - jaundice, other or unclassified
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   285,813,1971
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 214 ug/kg/1D
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Liver - jaundice, other or unclassified
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   285,813,1971
 
                            *** END OF RECORD ***