*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NM3453000
CHEMICAL NAME           : 1H-Indolo(3,2,1-de)pyrido(3,2,1-ij)-1,5-naphthyridine
                          , (-)-(3S,14R,16R)-16-ethyl-14-
                          hydroxymethyl-3,4,5,6,14,15,16,17,18,19-decahydro-
CAS REGISTRY NUMBER     : 108567-71-1
LAST UPDATED            : 198909
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C20-H26-N2-O
MOLECULAR WEIGHT        : 310.48
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (-)-(3-alpha,14-alpha,16-alpha)-14,15-Dihydroerburnamenine-14-methanol
   * Eburnamenine-14-methanol, 14,15-dihydro-, (3-alpha)-
   * RGH-0537
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   12,775,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   12,775,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   12,775,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   12,775,1987
 
                            *** END OF RECORD ***