*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AY2961800
CHEMICAL NAME           : D-Alaninamide,
                          N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-pheny
                          lalanyl-D-tryptophyl- L-seryl-L-tyrosyl-N(sup
                          6)-(bis(ethylamino)methylene)-D-lysyl-L-leucyl-L-argi
                          nyl-L-prolyl-
CAS REGISTRY NUMBER     : 89662-30-6
OTHER CAS REGISTRY NOS. : 105026-73-1
                          94608-19-2
BEILSTEIN REFERENCE NO. : 6564671
LAST UPDATED            : 199706
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C78-H105-Cl-N18-O13
MOLECULAR WEIGHT        : 1538.46
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
                          Hormone
SYNONYMS/TRADE NAMES :
   * N-Ac-D-Nal(2)1,D-pCl-Phe2,D-Trp3,D-hArg(Et2)6,D-Ala(10)-GnRH
   * Deterelix
   * Detirelix
   * RS-68439
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >40 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   17,505,1991
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1200 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - cyanosis
   Skin and Appendages - hair
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   17,505,1991
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   17,505,1991
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >500 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   17,505,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 34 mg/kg/12W-C
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
   Related to Chronic Data - changes in testicular weight
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   17,505,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 17 mg/kg/12W-C
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - changes in testicular weight
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   17,505,1991
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Human - woman
DOSE                    : 1400 ug/kg
SEX/DURATION            : female 27 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Maternal Effects - other effects
   Endocrine - changes in luteinizing hormone
REFERENCE :
   JCEMAZ Journal of Clinical Endocrinology and Metabolism.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.12-    1952-
   Volume(issue)/page/year: 72,927,1991
 
                            *** END OF RECORD ***