*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AU7450000
CHEMICAL NAME           : Adenosine 5'-(tetrahydrogen triphosphate), ruthenium
                          salt
CAS REGISTRY NUMBER     : 134981-39-8
LAST UPDATED            : 199303
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C10-H16-N5-O13-P3.Ru
MOLECULAR WEIGHT        : 608.29
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Ru-Atp
   * Ruthenium-5'-atp
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2390 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   56ZJAL "Metal Ions in Biology and Medicine, Proceedings of the International
   Symposium, 1st, 1990," Collery, P., and Manfait, M., et al., eds., Paris,
   France, 1990.  Volume(issue)/page/year: -,479,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   56ZJAL "Metal Ions in Biology and Medicine, Proceedings of the International
   Symposium, 1st, 1990," Collery, P., and Manfait, M., et al., eds., Paris,
   France, 1990.  Volume(issue)/page/year: -,479,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3060 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   56ZJAL "Metal Ions in Biology and Medicine, Proceedings of the International
   Symposium, 1st, 1990," Collery, P., and Manfait, M., et al., eds., Paris,
   France, 1990.  Volume(issue)/page/year: -,479,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   56ZJAL "Metal Ions in Biology and Medicine, Proceedings of the International
   Symposium, 1st, 1990," Collery, P., and Manfait, M., et al., eds., Paris,
   France, 1990.  Volume(issue)/page/year: -,479,1990
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1720 mg/kg/21D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes in urine composition
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   56ZJAL "Metal Ions in Biology and Medicine, Proceedings of the International
   Symposium, 1st, 1990," Collery, P., and Manfait, M., et al., eds., Paris,
   France, 1990.  Volume(issue)/page/year: -,479,1990
 
                            *** END OF RECORD ***