*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AY2961600
CHEMICAL NAME           : D-Alaninamide,
                          N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-pheny
                          lalanyl-3-(3-pyridiny
                          l)-D-alanyl-L-seryl-L-arginyl-5-(4-methoxyphenyl)-5-o
                          xo-D-norvalyl-L-leucy l-L-arginyl-L-prolyl-
CAS REGISTRY NUMBER     : 103733-02-4
LAST UPDATED            : 199312
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C73-H97-Cl-N18-O14
MOLECULAR WEIGHT        : 1486.33
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Ac-D-Nal(sup 1),D-4-Cl-Phe(sup 2),D-Pal(sup 3),Arg(sup 5),D-Glu(AA)(sup  
   6),D-Ala(sup 10)
   * Na1-G1u
   * ORF 21243
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22500 ug/kg/90D-I
TOXIC EFFECTS :
   Blood - changes in erythrocyte (RBC) count
   Related to Chronic Data - changes in ovarian weight
   Related to Chronic Data - changes in prostate weight
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   14,734,1990
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - woman
DOSE                    : 150 ug/kg
SEX/DURATION            : female 3 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Maternal Effects - other effects
   Endocrine - changes in luteinizing hormone
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 165,1811,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 37500 ug/kg
SEX/DURATION            : male 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   14,734,1990
 
                            *** END OF RECORD ***