*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NM2080500
CHEMICAL NAME           : 2-Indolinone
CAS REGISTRY NUMBER     : 59-48-3
BEILSTEIN REFERENCE NO. : 0114692
REFERENCE               : 5-21-08-00007 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C8-H7-N-O
MOLECULAR WEIGHT        : 133.16
WISWESSER LINE NOTATION : T56 BMV DHJ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1,3-Dihydro-2H-indol-2-one
   * 2H-Indol-2-one, 1,3-dihydro-
   * Oxindol
   * Oxindole
   * 2-Oxindole
   * 2-Oxindoline
   * 2-Oxoindoline
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 152,121,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 152,121,1964
 
                            *** END OF RECORD ***