*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NL5075000
CHEMICAL NAME           : Indole, 1-benzyl-3-(2-(4-pyridyl)ethyl)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 5585-71-7
LAST UPDATED            : 199009
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H20-N2.Cl-H
MOLECULAR WEIGHT        : 348.90
WISWESSER LINE NOTATION : T56 BNJ B1R& D2- DT6NJ &GH
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Benzindopyrine hydrochloride
   * 4-(1-Benzyl-3-indolethyl)pyridine hydrochloride
   * 1-Benzyl-3-(2-(4-pyridyl)ethyl)indole hydrochloride
   * IN 461
   * Purbenzindole
   * Pyrbenzindole
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 714 ug/kg/D
TOXIC EFFECTS :
   Behavioral - antianxiety
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   AMCTAH Antibiotic Medicine and Clinical Therapy (New York).  (New York, NY)
   V.3-8, 1956-61.  For publisher information, see CLMEA3.
   Volume(issue)/page/year: 6,521,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 125,122,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 98 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 125,122,1959
 
                            *** END OF RECORD ***