*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NL6015300
CHEMICAL NAME           : 1H-Indole-3-carboxylic acid,
                          octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester,
                          (2-alpha,6-alpha,8-alpha,9a-beta)-,
                          monomethanesulfonate, monohydrate
CAS REGISTRY NUMBER     : 115956-13-3
LAST UPDATED            : 199801
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H20-N2-O3.C-H4-O3-S.H2-O
MOLECULAR WEIGHT        : 438.54
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Anzemet
   * Dolasetron mesylate monohydrate
   * MDL 73147EF
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2400 ug/kg
TOXIC EFFECTS :
   Behavioral - headache
   Gastrointestinal - decreased motility or constipation
   Gastrointestinal - other changes
REFERENCE :
   BDDID8 Biopharmaceutics & Drug Disposition.  (John Wiley & Sons, Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1979-
   Volume(issue)/page/year: 18,361,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2400 ug/kg/10M-C
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - headache
REFERENCE :
   BDDID8 Biopharmaceutics & Drug Disposition.  (John Wiley & Sons, Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1979-
   Volume(issue)/page/year: 18,361,1997
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 545 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   18,506,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 165 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   18,506,1993
 
                            *** END OF RECORD ***