*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NL3150000
CHEMICAL NAME : 1H-Indole-3-acetic acid
CAS REGISTRY NUMBER : 87-51-4
LAST UPDATED : 199710
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C10-H9-N-O2
MOLECULAR WEIGHT : 175.20
WISWESSER LINE NOTATION : T56 BMJ D1VQ
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Indol-3-ylacetic acid
* Acetic acid, indolyl-
* Heteroauxin
* Hexteroauxin
* IAA
* 3-Iaa
* beta-Indoleacetic acid
* beta-Indole-3-acetic acid
* 3-Indoleacetic acid
* alpha-Indol-3-yl-acetic acid
* beta-Indolylacetic acid
* Indolyl-3-acetic acid
* 3-Indolylacetic acid
* Kyselina 3-indolyloctova
* Rhizopin
* Rhizopon A
* omega-Skatole carboxylic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,7,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2000 mg/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumor types after systemic administration not seen
spontaneously
REFERENCE :
AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium) V.1-20,
1936-64. For publisher information, see IJCNAW. Volume(issue)/page/year:
19,660,1963
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 4500 mg/kg
SEX/DURATION : female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 19,321,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 450 mg/kg
SEX/DURATION : female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 19,321,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 4500 mg/kg
SEX/DURATION : female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 19,321,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 4500 mg/kg
SEX/DURATION : female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 19,321,1979
** MUTATION DATA **
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Mold - Aspergillus nidulans
DOSE/DURATION : 1150 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 4,1409,1983
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Mold - Aspergillus nidulans
DOSE/DURATION : 1150 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 4,1409,1983
TYPE OF TEST : DNA damage
TEST SYSTEM : Fish - salmon Sperm
DOSE/DURATION : 250 umol/L
REFERENCE :
PYTCAS Phytochemistry. An International Journal of Plant Biochemistry.
(Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-
1961- Volume(issue)/page/year: 11,3135,1972
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 100 nmol/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 32,29,1976
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,109,1990
TYPE OF TEST : DNA damage
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 250 umol/L
REFERENCE :
PYTCAS Phytochemistry. An International Journal of Plant Biochemistry.
(Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-
1961- Volume(issue)/page/year: 11,3135,1972
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83421
No. of Facilities: 5 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 27 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***