*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NK8390355
CHEMICAL NAME           : 1H-Indene-1,3(2H)-dione,
                          2-((dimethylamino)methylene)-
CAS REGISTRY NUMBER     : 28752-91-2
LAST UPDATED            : 199701
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C12-H11-N-O2
MOLECULAR WEIGHT        : 201.24
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * COR 3761
   * Dimethylaminomethylene-2 indanedione-1,3
   * 2-((Dimethylamino)methylene)-1H-indene-1,3(2H)-dione
   * 1,3-Indandione, 2-((dimethylamino)methylene)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #0172128
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 440 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle weakness
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 10,320,1976
 
                            *** END OF RECORD ***