*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NJ5099400
CHEMICAL NAME           : 1H-Imidazo(1,2-c)pyrazolo(3,4-e)pyrimidine,
                          5-ethyl-1,3,8-trimethyl-
CAS REGISTRY NUMBER     : 89239-93-0
LAST UPDATED            : 199706
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C12-H14-N5
MOLECULAR WEIGHT        : 228.31
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 5-Ethyl-1,3,8-trimethyl-1H-imidazo(1,2-c)pyrazolo(3,4-e)pyrimidine
   * PD 112488
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 350 mg/kg/14D-C
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - structural or functional changes in ureter
   Kidney, Ureter, Bladder - changes in bladder weight
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 22,39,1994
 
                            *** END OF RECORD ***