*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NJ2441000
CHEMICAL NAME           : 4-Imidazoline-1-carboxylic acid, 3-methyl-2-thioxo-,
                          ethyl ester
CAS REGISTRY NUMBER     : 22232-54-8
BEILSTEIN REFERENCE NO. : 0144339
REFERENCE               : 4-24-00-00064 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C7-H10-N2-O2-S
MOLECULAR WEIGHT        : 186.25
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * Athyromazole
   * Basolest
   * Carbethoxymethimazole
   * Carbimazol
   * Carbimazole
   * CG1
   * 1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo, ethyl  
   ester
   * 3-Methyl-2-thioxo-4-imidazoline-1-carboxylic acid ethyl ester
   * Neomercazole
   * Tyrazol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 703 mg/kg/17W-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Ear) - change in acuity
   Sense Organs and Special Senses (Ear) - tinnitus
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   309,929,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 25 mg/kg/6W-I
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), diffuse
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 145,1513,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 23 mg/kg/5W-I
TOXIC EFFECTS :
   Liver - jaundice, cholestatic
REFERENCE :
   JRSMD9 Journal of the Royal Society of Medicine.  (Oxford Univ. Press,
   Walton St., Oxford OX2 6DP, UK)  V.71-    1978-  Volume(issue)/page/year:
   78,75,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1 mg/kg/1D-I
TOXIC EFFECTS :
   Liver - jaundice, other or unclassified
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   309,438,1983
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 1 gm/L
REFERENCE :
   CHINAG Chemistry and Industry (London).  (Royal Soc. of Chemistry,
   Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK)  V.1-
   1923-  Volume(issue)/page/year: (21),847,1980
 
                            *** END OF RECORD ***