*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NJ0400000
CHEMICAL NAME           : 2-Imidazolidinethione, 4-methyl-
CAS REGISTRY NUMBER     : 2122-19-2
LAST UPDATED            : 198910
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C4-H8-N2-S
MOLECULAR WEIGHT        : 116.20
WISWESSER LINE NOTATION : T5MYMTJ BUS D1
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 4-Methylethylenethiourea
   * 4-Methyl-2-imidazolidinethione
   * PLTU
   * Propilentiourea
   * Propylene thiourea
   * Propylenthioharnstoff
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 17,235,1982
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 75 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   MVMZA8 Monatshefte fuer Veterinaermedizin.  (VEB Gustav Fischer Verlag,
   Postfach 176, Jena DDR-6900, Ger. Dem. Rep.)  V.1-    1946-
   Volume(issue)/page/year: 33,137,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   MVMZA8 Monatshefte fuer Veterinaermedizin.  (VEB Gustav Fischer Verlag,
   Postfach 176, Jena DDR-6900, Ger. Dem. Rep.)  V.1-    1946-
   Volume(issue)/page/year: 33,137,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2400 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   MVMZA8 Monatshefte fuer Veterinaermedizin.  (VEB Gustav Fischer Verlag,
   Postfach 176, Jena DDR-6900, Ger. Dem. Rep.)  V.1-    1946-
   Volume(issue)/page/year: 33,137,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 450 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale.  (Casa
   Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy)  V.2- 1927- 
   Volume(issue)/page/year: 61,271,1985
 
                            *** END OF RECORD ***