*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NI6732550
CHEMICAL NAME           : 1H-Imidazole-5-methanol,
                          2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-
                          biphenyl)-4-yl)methyl)-
CAS REGISTRY NUMBER     : 114798-26-4
LAST UPDATED            : 199807
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H23-Cl-N6-O
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * DUP 89
   * Losartan
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 42 mg/kg/6W-I
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   124,775,1996
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 17500 ug/kg/17W-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Taste) - change in function
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 347,471,1996
 
                            *** END OF RECORD ***