*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NI5566000
CHEMICAL NAME           : Imidazole-1-ethanol, alpha-(fluoromethyl)-2-nitro-
CAS REGISTRY NUMBER     : 13551-89-8
BEILSTEIN REFERENCE NO. : 0522249
REFERENCE               : 5-23-04-00475 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C6-H8-F-N3-O3
MOLECULAR WEIGHT        : 189.17
WISWESSER LINE NOTATION : T5N CNJ A1YQ1F BNW
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * alpha-(Fluoromethyl)-2-nitroimidazole-1-ethanol
   * 1-(2-Nitro-1-imidazolyl)-3-fluoro-2-propanol
   * NSC 292930
   * Ro-07-0741
   * SR 1369
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RAREAE Radiation Research.  (Academic Press, Inc., 1 E. First St., Duluth,
   MN 55802)  V.1-    1954-  Volume(issue)/page/year: 91,186,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4371540
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 58,1,1978
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 1 mmol/L/3D (Continuous)
REFERENCE :
   45OJAG "Radiation Sensitizers: Their Use in the Clinical Management of
   Cancer, Proceedings of the Conference, Key Biscayne, FL, 1979," Brady, L.W.,
   ed., New York, Masson Pub. USA, Inc., 1980  Volume(issue)/page/year:
   -,146,1980

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***