*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NI3340000
CHEMICAL NAME : Imidazole-1-acetamide, N-benzyl-2-nitro-
CAS REGISTRY NUMBER : 22994-85-0
BEILSTEIN REFERENCE NO. : 0551486
REFERENCE : 5-23-04-00478 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C12-H12-N4-O3
MOLECULAR WEIGHT : 260.28
WISWESSER LINE NOTATION : T5N CNJ A1VM1R& BNW
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acetamide, N-benzyl-2-(nitroimidazol-1-yl)-
* Benznidazole
* N-Benzyl-2-nitroimidazole-1-acetamide
* N-Benzyl-2-nitro-1-imidazoleacetamide
* 1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)-
* 2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide
* Radanil
* Ro 71051
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 8 gm/kg
SEX/DURATION : male 8 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
REFERENCE :
COBIEJ Communicaciones Biologicas. (Communicaciones Biologicas, c/o Dr.
Amanda Pellegrino de Iraldi, Instituto de Biologia Cellular, Faculated de
Medicina, Paraguay 2155, Buenos Aires, 1121, Argentina) V.1- 1982-
Volume(issue)/page/year: 8,251,1990
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 ug/plate
REFERENCE :
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao
Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao
Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
Volume(issue)/page/year: 19,19,1986
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 10 mg/L
REFERENCE :
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of
Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921-
Volume(issue)/page/year: 58,505,1983
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Klebsiella pneumoniae
DOSE/DURATION : 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 31,149,1975
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 380 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
34,1457,1985
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 200 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 320,305,1994
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Human
DOSE/DURATION : 150 mg/kg/30D (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,217,1988
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 25 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 230,305,1994
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 320,305,1994
*** END OF RECORD ***