*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NI3915000
CHEMICAL NAME           : Imidazole-4-carboxamide, 5-amino-, compd. with orotic
                          acid (1:1), dihydrate
CAS REGISTRY NUMBER     : 2574-78-9
LAST UPDATED            : 199009
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C9-H10-N6-O5.2H2-O
MOLECULAR WEIGHT        : 318.29
WISWESSER LINE NOTATION : T6MVMVJ FVQ &T5M CNJ DVZ EZ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Aica orotate dihydrate
   * Aicamin dihydrate
   * Aicorat dihydrate
   * 4-Amino-5-imidazolecarboxamide orotate dihydrate
   * 5-Aminoimidazole-4-carboxamide orotate dihydrate
   * Orotic acid compd. with 5(or 4)-aminoimidazole-4(or 5)-carboxamide (1:1)  
   dihydrate
   * Orazamide dihydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   YKKKA8 Yakugaku Kenkyu.  Japanese Journal of Pharmacy and Chemistry. (Osaka,
   Japan)  V.1-39, 1929-68.  Discontinued.  Volume(issue)/page/year: 35,94,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   YKKKA8 Yakugaku Kenkyu.  Japanese Journal of Pharmacy and Chemistry. (Osaka,
   Japan)  V.1-39, 1929-68.  Discontinued.  Volume(issue)/page/year: 35,94,1963
 
                            *** END OF RECORD ***