*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MW5150000
CHEMICAL NAME : Hydrocinnamic acid,
3,5-diiodo-4-hydroxy-alpha-phenyl-
CAS REGISTRY NUMBER : 577-91-3
BEILSTEIN REFERENCE NO. : 2700381
REFERENCE : 4-10-00-01291 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C15-H12-I2-O3
MOLECULAR WEIGHT : 494.07
WISWESSER LINE NOTATION : QVYR&1R DQ CI EI
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Biliognost
* Biliselectan
* beta-(3,5-Diiodo-4-hydroxyphenyl)-alpha-phenylpropionic acid
* 3,5-Diiodo-alpha-phenylphloretic acid
* Dikol
* beta-(4-Hydroxy-3,5-diiodophenyl)-alpha-phenylpropionic acid
* Iodoalphionic acid
* Iodobil
* beta-(4-Oxy-3,5-dijod-phenyl)-alpha-phenyl-propionsaeure
* Jodobil
* Pheniodol
* Priodax
* Propionic acid, 3-(3,5-diiodo-4-hydroxyphenyl)-2-phenyl-
* Tenicid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1100 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - muscle contraction or spasticity
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
20,125,1941
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 510 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - antipsychotic
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 42,476,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 540 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - muscle contraction or spasticity
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
20,125,1941
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 390 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
20,125,1941
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2950 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - antipsychotic
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 42,476,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 640 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - antipsychotic
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 42,476,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 13,997,1970
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - food intake (animal)
Gastrointestinal - nausea or vomiting
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830
Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-
Volume(issue)/page/year: 27,1376,1942
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830
Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-
Volume(issue)/page/year: 27,1376,1942
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 930 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - antipsychotic
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 42,476,1953
*** END OF RECORD ***