*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MU7700000
CHEMICAL NAME           : Hydrazine, 1-acetyl-2-picolinoyl-
CAS REGISTRY NUMBER     : 17433-31-7
BEILSTEIN REFERENCE NO. : 0392704
LAST UPDATED            : 199612
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C8-H9-N3-O2
MOLECULAR WEIGHT        : 179.20
WISWESSER LINE NOTATION : T6NJ BVMMV1
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
SYNONYMS/TRADE NAMES :
   * N-Acetyl-N'-isonicotinyl hydrazide
   * 1-Acetyl-2-picolinolhydrazine
   * 1-Acetyl-2-picolinoylhydrazine
   * Azapicyl
   * NCI-C04739
   * NSC-68626
   * P-2292
   * 2-Pyridinecarboxylic acid, 2-acetylhydrazide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 673 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,169,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 470 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,169,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 410 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,169,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 255 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,169,1965
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,169,1965
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 576 mg/kg/24D-I
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Gastrointestinal - nausea or vomiting
   Endocrine - other changes
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,169,1965
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 1152 mg/kg/24D-I
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - proteinuria
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,169,1965
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9750 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   RRCRBU Recent Results in Cancer Research.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1965-
   Volume(issue)/page/year: 52,1,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9750 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
   RRCRBU Recent Results in Cancer Research.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1965-
   Volume(issue)/page/year: 52,1,1975

                          *** STATUS IN U.S. ***
 
   NCI Carcinogenesis Studies (ipr);clear evidence:mouse,rat
   RRCRBU Recent Results in Cancer Research.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1965-
   Volume(issue)/page/year: 52,1,75

 
                            *** END OF RECORD ***