*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MJ9653000
CHEMICAL NAME           : 5-Heptenoic acid,
                          7-(3,5-dihydroxy-2-(3-hydroxy-1-decenyl)cyclopentyl)-
                          , (1R-(1-alpha(Z),2-beta(1E,3S*),3-alpha,5-alpha))-
CAS REGISTRY NUMBER     : 36950-85-3
LAST UPDATED            : 198910
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C22-H38-O5
MOLECULAR WEIGHT        : 382.60
WISWESSER LINE NOTATION : L5TJ AQ B6VQ C1U1YQ7 DQ
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 20-Ethyl-pgf2-alpha
   * 20-Ethylprostaglandin F2-alpha
   * ICI 74205
   * racemic-ICI 74205
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4 mg/kg
SEX/DURATION            : female 4-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   PRGLBA Prostaglandins.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1972-  Volume(issue)/page/year: 2,375,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 40 mg/kg
SEX/DURATION            : female 19-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   PRGLBA Prostaglandins.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1972-  Volume(issue)/page/year: 2,375,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 4-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   PRGLBA Prostaglandins.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1972-  Volume(issue)/page/year: 2,375,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 2250 ug/kg
SEX/DURATION            : female 4-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 238,400,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 100 ug/kg
SEX/DURATION            : female 4-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 238,400,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 150 ug/kg
SEX/DURATION            : female 4-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 238,400,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 2500 ug/kg
SEX/DURATION            : female 14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   PRGLBA Prostaglandins.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1972-  Volume(issue)/page/year: 2,375,1972
 
                            *** END OF RECORD ***