*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MJ8810000
CHEMICAL NAME : 5-Heptenamide,
7-(3-hydroxy-2-(3-hydroxy-4-phenoxy-1-butenyl)-5-oxoc
yclopentyl)- N-(methylsulfonyl)-,
(1R-(1-alpha(Z),2-beta(1E,3R*),3-alpha))-
CAS REGISTRY NUMBER : 60325-46-4
LAST UPDATED : 199803
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C23-H31-N-O7-S
MOLECULAR WEIGHT : 465.61
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
Hormone
SYNONYMS/TRADE NAMES :
* CP 34089
* 16-Phenoxy-omega-17,18,19,20-tetranor pge-2 methylsulfonylamide
* 16-Phenoxy-omega-17,18,19,20-tetranor prostaglandin E2
methylsulfonylamide
* 16-Phenoxy-17,18,19,20 tetranor prostaglandin E(sub 2) methyl
sulfonylamide
* Sch 286
* SHB 286
* Sulprostone
* ZK 57671
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and
Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049
Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 56(4),37,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and
Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049
Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 56(4),37,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and
Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049
Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 56(4),37,1993
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - woman
DOSE : 17 ug/kg
SEX/DURATION : female 23 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 137,8,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - woman
DOSE : 10 ug/kg
SEX/DURATION : female 9 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 19,29,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - woman
DOSE : 20 ug/kg
SEX/DURATION : female 49 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 22,471,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - woman
DOSE : 30 ug/kg
SEX/DURATION : female 15 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 26,279,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - woman
DOSE : 15 ug/kg
SEX/DURATION : female 7 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Fertility - abortion
REFERENCE :
GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79
Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year:
29,10,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - woman
DOSE : 5 ug/kg
SEX/DURATION : female 10 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 27,51,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraplacental
SPECIES OBSERVED : Human - woman
DOSE : 500 ng/kg
SEX/DURATION : female 15 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 26,279,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intracervical
SPECIES OBSERVED : Human - woman
DOSE : 1 ug/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 16,377,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 550 mg/kg
SEX/DURATION : female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and
Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049
Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 56(4),37,1993
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Primate - monkey
DOSE : 900 ug/kg
SEX/DURATION : female 21-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
44LQAF "International Sulprostone Symposium, Papers, Vienna, 1978," Friebel,
K., et al., eds., Berlin, Fed. Rep. Ger., Schering AG, 1979
Volume(issue)/page/year: -,39,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE : 120 ug/kg
SEX/DURATION : female 63-64 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica,
Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948-
Volume(issue)/page/year: 253,148,1983
*** END OF RECORD ***