*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MF1750000
CHEMICAL NAME : Guanidine, dodecyl-, acetate
CAS REGISTRY NUMBER : 2439-10-3
OTHER CAS REGISTRY NOS. : 96923-04-5
LAST UPDATED : 199707
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C13-H29-N3.C2-H4-O2
MOLECULAR WEIGHT : 287.51
WISWESSER LINE NOTATION : MUYZM12 &OV1
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Aadodin
* AC 5223
* American cyanamid 5223
* Carpene
* Curitan
* Cyprex
* Cyprex 65W
* Dodecylguanidine acetate
* n-Dodecylguanidine acetate
* Dodin
* Dodine
* Dodine acetate
* Dodine, mixture with glyodin
* Doguadine
* ENT 16,436
* Experimental fungicide 5223
* Karpen
* Kyselina 3-dodecylguanidinooctova
* Laurylguanidine acetate
* Melprex
* Melprex 65
* Melprex Liquid Dodine
* Melprex 65W
* Radspor
* Syllit
* Tsitrex
* Venturol
* Vondodine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,975,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 660 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
3,127,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C116,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,239,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 266 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,64,1982
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 129 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,64,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 535 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,64,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2100 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach
Blood - hemorrhage
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
3,127,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 176 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,64,1982
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,64,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 788 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,326,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 1142 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,326,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 18816 mg/kg/14W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
3,127,1961
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 35040 mg/kg/2Y-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
3,127,1961
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1000 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2872
No. of Facilities: 226 (estimated)
No. of Industries: 7
No. of Occupations: 7
No. of Employees: 1925 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M2872
No. of Facilities: 27 (estimated)
No. of Industries: 5
No. of Occupations: 18
No. of Employees: 1403 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
*** END OF RECORD ***