*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MG8750000
CHEMICAL NAME           : Harmaline, hydrochloride, dihydrate
CAS REGISTRY NUMBER     : 6027-98-1
LAST UPDATED            : 199106
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C13-H14-N2-O.Cl-H.2H2-O
MOLECULAR WEIGHT        : 286.79
WISWESSER LINE NOTATION : T B656 EN HM EUT&&J F1 KO1 &GH &QH 2
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TRSEAO Transactions of the Royal Society of Edinburgh.  (Edinburgh,
   Scotland)  V.1-70, 1783-1979.  Volume(issue)/page/year: 47,245,1909
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TRSEAO Transactions of the Royal Society of Edinburgh.  (Edinburgh,
   Scotland)  V.1-70, 1783-1979.  Volume(issue)/page/year: 47,245,1909
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TRSEAO Transactions of the Royal Society of Edinburgh.  (Edinburgh,
   Scotland)  V.1-70, 1783-1979.  Volume(issue)/page/year: 47,245,1909
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TRSEAO Transactions of the Royal Society of Edinburgh.  (Edinburgh,
   Scotland)  V.1-70, 1783-1979.  Volume(issue)/page/year: 47,245,1909
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TRSEAO Transactions of the Royal Society of Edinburgh.  (Edinburgh,
   Scotland)  V.1-70, 1783-1979.  Volume(issue)/page/year: 47,245,1909
 
                            *** END OF RECORD ***