*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MG1400000
CHEMICAL NAME           : Gutierrezia microcephala, leaf
LAST UPDATED            : 199409
DATA ITEMS CITED        : 5
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Snakeweed
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 70 gm/kg/14D-C
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   70(Suppl 1),125,1992
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 gm/kg/
SEX/DURATION            : female 3-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   71,2193,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 27 gm/kg/
SEX/DURATION            : female 5-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   71,2193,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 gm/kg/
SEX/DURATION            : female 2-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   71,2193,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 35 gm/kg
SEX/DURATION            : female 7 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   71,2193,1993
 
                            *** END OF RECORD ***