*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MG1019000
CHEMICAL NAME           : Gunacin
CAS REGISTRY NUMBER     : 73341-70-5
BEILSTEIN REFERENCE NO. : 1332129
REFERENCE               : 5-18-05-00435 (Beilstein Handbook Reference)
LAST UPDATED            : 199806
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C17-H16-O8
MOLECULAR WEIGHT        : 348.33
WISWESSER LINE NOTATION : T C666 BV DO IVT&&J E1 FQ GOV1 KQ MO1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * 2H-Naphtho(2,3-b)pyran-5,10-dione,  
   3,4-dihydro-4-(acetyloxy)-3,6-dihydroxy-8-methoxy-2-methyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Behavioral - irritability
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 32,1104,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Behavioral - irritability
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 32,1104,1979
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2100 mg/kg/21D-I
TOXIC EFFECTS :
   Endocrine - other changes
   Blood - changes in spleen
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   JPTLAS Journal of Pathology.  (John Wiley & Sons, Inc., 605 Third Ave., New
   York, NY 10158) V.97-    1969-  Volume(issue)/page/year: 138,163,1982
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 200 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 32,1104,1979
 
                            *** END OF RECORD ***