*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MF4630000
CHEMICAL NAME           : Guanidine, 3-nitro-1-nitroso-1-pentyl-
CAS REGISTRY NUMBER     : 13010-10-1
BEILSTEIN REFERENCE NO. : 1975840
LAST UPDATED            : 199612
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C6-H13-N5-O3
MOLECULAR WEIGHT        : 203.24
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * N-(n-Amyl)-N'-nitro-N-nitrosoguanidine
   * Guanidine, N'-nitro-N-nitroso-N-pentyl-
   * 1-Nitroso-3-nitro-1-pentylguanidine
   * NSC 34699
   * 1-Pentyl-3-nitro-1-nitrosoguanidine
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 69 mg/kg/5W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   69,277,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 nmol/plate
REFERENCE :
   IDZAAW Japanese Journal of Genetics.  Idengaku Zasshi.  (Genetics Soc. of
   Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan)  V.1-    1921-
   Volume(issue)/page/year: 50,403,1975
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 mg/L
REFERENCE :
   ESKHA5 Eisei Shikenjo Hokoku.  Bulletin of the Institute of Hygienic
   Sciences.  (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
   Setagaya-ku, Tokyo 158, Japan)  V.1-    1886-  Volume(issue)/page/year:
   (88),118,1970
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1500 ug/L
REFERENCE :
   APMBAY Applied Microbiology.  (Washington, DC)  V.1-30, 1953-75.  For
   publisher information, see AEMIDF.  Volume(issue)/page/year: 23,91,1972
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 2 umol/well
REFERENCE :
   IDZAAW Japanese Journal of Genetics.  Idengaku Zasshi.  (Genetics Soc. of
   Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan)  V.1-    1921-
   Volume(issue)/page/year: 50,403,1975
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 30 mg/L/24H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,337,1977
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 16 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***