*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MF4220000
CHEMICAL NAME           : Guanidine, 1-methyl-3-nitro- mixed with sodium
                          nitrite (1:1)
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 1-Methyl-3-nitroguanidine mixed with sodium nitrite (1:1)
   * Sodium nitrite mixed with 1-methyl-3-nitroguanidine (1:1)
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 90 gm/kg/67W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 23(8),54,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 100 umol/L/3H
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 16,284,1975
 
                            *** END OF RECORD ***