*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MF3860000
CHEMICAL NAME           : Guanidine, 1,1'-((methylethanediylidene)dinitrilo)di-
CAS REGISTRY NUMBER     : 459-86-9
OTHER CAS REGISTRY NOS. : 75020-13-2
BEILSTEIN REFERENCE NO. : 1912590
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C5-H12-N8
MOLECULAR WEIGHT        : 184.25
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Hydrazinecarboximidamide, 2,2'-(1-methyl-1,2-ethanediylidene)bis-
   * 1,1'-((Methylethanediylidene)dinitrilo)diguanidine
   * Methyl-G
   * Methyl-gag
   * Methylglyoxal bis(guanylhydrazone)
   * Mitoguazone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ADTEAS Advances in Teratology.  (New York, NY)  V.1-5, 1966-72.
   Discontinued.  Volume(issue)/page/year: 3,181,1968
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1260 mg/kg
SEX/DURATION            : male 7 day(s) pre-mating
                          female 7 day(s) pre-mating  - 7 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   SMBUA9 Stanford Medical Bulletin.  (Palo Alto, CA)  V.1-20, 1942-62.
   Discontinued.  Volume(issue)/page/year: 20,152,1962
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 500 mg/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   51,213,1990
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Mammal - cattle Lymphocyte
DOSE/DURATION           : 8 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   37,3169,1977
 
                            *** END OF RECORD ***